FCER1G
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Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide is a protein that in humans is encoded by the FCER1G gene. [1]
Function
The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008].
References
- ↑ "Entrez Gene: Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide". Retrieved 2013-12-30.
Further reading
- Tsuji, M.; Ezumi, Y.; Arai, M.; Takayama, H. (1997). "A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets". The Journal of Biological Chemistry. 272 (38): 23528–23531. doi:10.1074/jbc.272.38.23528. PMID 9295288.
- Kihara, H.; Siraganian, R. P. (1994). "Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor". The Journal of Biological Chemistry. 269 (35): 22427–22432. PMID 8071371.
- Huang, L.; Chen, S.; Zha, X.; Yang, L.; Li, B.; Yu, Z.; Wang, L.; Li, Y. (2012). "Expression feature of CD3, FcεRIγ, and Zap-70 in patients with chronic lymphocytic leukemia". Hematology. 17 (2): 71–75. doi:10.1179/102453312X13221316477895. PMID 22664044.
- Kim, Y. -K.; Park, H. -W.; Yang, J. -S.; Oh, S. -Y.; Chang, Y. -S.; Shin, E. -S.; Lee, J. -E.; Kim, S.; Gho, Y. S.; Cho, S. -H.; Min, K. -U.; Kim, Y. -Y. (2007). "Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor ? Chain gene, to airway hyper-responsiveness". Clinical & Experimental Allergy. 37 (4): 592–598. doi:10.1111/j.1365-2222.2007.02680.x. PMID 17430357.
- Zha, X.; Yan, X.; Shen, Q.; Zhang, Y.; Wu, X.; Chen, S.; Li, B.; Yang, L.; Geng, S.; Weng, J.; Du, X.; Li, Y. (2012). "Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia". Journal of Hematology & Oncology. 5: 74. doi:10.1186/1756-8722-5-74. PMC 3544630
. PMID 23228155. - Takahashi, K.; Hayashi, N.; Shimokawa, T.; Umehara, N.; Kaminogawa, S.; Ra, C. (2008). "Cooperative Regulation of Fc Receptor -Chain Gene Expression by Multiple Transcription Factors, Including Sp1, GABP, and Elf-1". Journal of Biological Chemistry. 283 (22): 15134–15141. doi:10.1074/jbc.M800498200. PMC 3258888. PMID 18378679.
- Bao, M.; Hanabuchi, S.; Facchinetti, V.; Du, Q.; Bover, L.; Plumas, J.; Chaperot, L.; Cao, W.; Qin, J.; Sun, S. -C.; Liu, Y. -J. (2012). "CD2AP/SHIP1 Complex Positively Regulates Plasmacytoid Dendritic Cell Receptor Signaling by Inhibiting the E3 Ubiquitin Ligase Cbl". The Journal of Immunology. 189 (2): 786–792. doi:10.4049/jimmunol.1200887. PMC 3665352. PMID 22706086.
- Gross, B. S.; Melford, S. K.; Watson, S. P. (1999). "Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets". European Journal of Biochemistry / FEBS. 263 (3): 612–623. doi:10.1046/j.1432-1327.1999.00560.x. PMID 10469124.
- Kumar, P.; Singh, B.; Lal, R.; Rembhotkar, G. W.; Singh, A. B. (2009). "Association between reduced levels of total serum IgE and FcεRI expression in non-releaser basophils". Immunobiology. 214 (5): 377–383. doi:10.1016/j.imbio.2008.09.008. PMID 19362683.
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