Exoribonuclease H

Exoribonuclease H
Identifiers
EC number 3.1.13.2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Exoribonuclease H (EC 3.1.13.2) is an enzyme.[1] This enzyme catalyses the following chemical reaction

3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid

This is a secondary reaction to the RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end performed by EC 3.1.26.13 (retroviral ribonuclease H).

References

  1. Schatz, O.; Mous, J.; Le Grice, S.F. (1990). "HIV-1 RT-associated ribonuclease H displays both endonuclease and 35 exonuclease activity". EMBO J. 9: 1171–1176. PMID 1691093.
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