Enterovirus cis-acting replication element

Enterovirus cis-acting replication element
Predicted secondary structure and sequence conservation of Entero_CRE
Identifiers
Symbol Entero_CRE
Alt. Symbols CRE
Rfam RF00048
Other data
RNA type Cis-reg
Domain(s) Viruses
SO 0000233

Enterovirus cis-acting replication element is a small RNA hairpin in the coding region of protein 2C as the site in PV1(M) RNA that is used as the primary template for the in vitro uridylylation.[1][2] The first step in the replication of the plus-stranded poliovirus RNA is the synthesis of a complementary minus strand. This process is initiated by the covalent attachment of uridine monophosphate (UMP) to the terminal protein VPg, yielding VPgpU and VPgpUpU.

See also

References

  1. Paul, AV; Rieder E; Kim DW; van Boom JH; Wimmer E (2000). "Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg". J Virol. 74 (22): 1035910370. doi:10.1128/JVI.74.22.10359-10370.2000. PMC 110910Freely accessible. PMID 11044080.
  2. Goodfellow, I; Chaudhry Y; Richardson A; Meredith J; Almond JW; Barclay W; Evans DJ (2000). "Identification of a cis-acting replication element within the poliovirus coding region". J Virol. 74 (10): 45904600. doi:10.1128/JVI.74.10.4590-4600.2000. PMC 111979Freely accessible. PMID 10775595.

External links

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