Enamidase
enamidase | |||||||||
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Identifiers | |||||||||
EC number | 3.5.2.18 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, an enamidase (EC 3.5.2.18) is an enzyme that catalyzes the chemical reaction
- 6-oxo-1,4,5,6-tetrahydronicotinate + 2 H2O 2-formylglutarate + NH3
Thus, the two substrates of this enzyme are 6-oxo-1,4,5,6-tetrahydronicotinate and H2O, whereas its two products are 2-formylglutarate and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase.
References
- Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ (2006). "Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri". Proc. Natl. Acad. Sci. U.S.A. 103 (33): 12341–6. doi:10.1073/pnas.0601635103. PMC 1562527. PMID 16894175.
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