Deoxyribose-phosphate aldolase

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming). Other names in common use include phosphodeoxyriboaldolase, deoxyriboaldolase, deoxyribose-5-phosphate aldolase, 2-deoxyribose-5-phosphate aldolase, and 2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase. This enzyme participates in pentose phosphate pathway.

Structural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1JCJ, 1JCL, 1KTN, 1MZH, 1N7K, 1O0Y, 1P1X, 1UB3, 1VCV, and 2A4A.

References

Hoffee PA (1968). "2-deoxyribose-5-phosphate aldolase of Salmonella typhimurium: purification and properties". Arch. Biochem. Biophys. 126 (3): 795–802. doi:10.1016/0003-9861(68)90473-6. PMID 4879701.
Jedziniak JA, Lionetti FJ (1970). "Purification and properties of deoxyriboaldolase from human erythrocytes". Biochim. Biophys. Acta. 212 (3): 478–87. doi:10.1016/0005-2744(70)90254-8. PMID 4989681.
RACKER E (1952). "Enzymatic synthesis and breakdown of desoxyribose phosphate". J. Biol. Chem. 196 (1): 347–65. PMID 12980976.
Hoffee P, Rosen OM, Horecker BL (1965). "The mechanism of action of aldolases. VI. Crystallization of deoxyribose 5-phosphate aldolase and the number of active sites". J. Biol. Chem. 240: 1512–1516.

Carbon-carbon lyases (EC 4.1)

4.1.1: Carboxy-lyases	Acetoacetate decarboxylase Adenosylmethionine decarboxylase Aromatic L-amino acid decarboxylase Glutamate decarboxylase Histidine decarboxylase Lysine decarboxylase Malonyl-CoA decarboxylase Ornithine decarboxylase Oxaloacetate decarboxylase Phosphoenolpyruvate carboxykinase Phosphoenolpyruvate carboxylase Phosphoribosylaminoimidazole carboxylase Pyrophosphomevalonate decarboxylase Pyruvate decarboxylase RuBisCO Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase Uroporphyrinogen III decarboxylase

4.1.2: Aldehyde-lyases	Fructose-bisphosphate aldolase Aldolase A Aldolase B Aldolase C 2-hydroxyphytanoyl-CoA lyase Threonine aldolase

4.1.3: Oxo-acid-lyases	Isocitrate lyase 3-hydroxy-3-methylglutaryl-CoA lyase

4.1.99: Other	Tryptophanase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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