DOK4

DOK4

Identifiers

DOK4, IRS-5, IRS5, docking protein 4

External IDs

MGI: 2148865 HomoloGene: 10009 GeneCards: DOK4

Gene ontology
Molecular function	• signal transducer activity, downstream of receptor • protein binding • insulin receptor binding
Cellular component	• intracellular
Biological process	• nervous system development • MAPK cascade • transmembrane receptor protein tyrosine kinase signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


55715


114255


ENSG00000125170


ENSMUSG00000040631


Q8TEW6


Q99KE3

RefSeq (mRNA)


NM_018110


NM_053246

RefSeq (protein)


NP_060580.2


NP_444476.1

Location (UCSC)

Chr 16: 57.47 – 57.49 Mb

Chr 8: 94.86 – 94.88 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Docking protein 4 is a protein that in humans is encoded by the DOK4 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
↑ "Entrez Gene: DOK4 docking protein 4".

Further reading

Al-Sarraf N, Reiff JN, Hinrichsen J, et al. (2007). "DOK4/IRS-5 expression is altered in clear cell renal cell carcinoma.". Int. J. Cancer. 121 (5): 992–8. doi:10.1002/ijc.22776. PMID 17443497.
Uchida M, Enomoto A, Fukuda T, et al. (2007). "Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase.". J. Cell. Sci. 119 (Pt 15): 3067–77. doi:10.1242/jcs.03043. PMID 16820412.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cai D, Dhe-Paganon S, Melendez PA, et al. (2003). "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.". J. Biol. Chem. 278 (28): 25323–30. doi:10.1074/jbc.M212430200. PMID 12730241.
Favre C, Gérard A, Clauzier E, et al. (2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells.". Genes Immun. 4 (1): 40–5. doi:10.1038/sj.gene.6363891. PMID 12595900.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Grimm J, Sachs M, Britsch S, et al. (2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.". J. Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823.

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