DNA polymerase nu

POLN

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
4XVI, 4XVK, 4XVL, 4XVM

Identifiers

Aliases

POLN, POL4P, polymerase (DNA) nu

External IDs

HomoloGene: 129696 GeneCards: POLN

Genetically Related Diseases

Alzheimer's disease^[1]

Gene ontology
Molecular function	• transferase activity • DNA binding • nucleotidyltransferase activity • 5'-3' exonuclease activity • protein binding • cyclin binding • nucleic acid binding • DNA-directed DNA polymerase activity
Cellular component	• cytoplasm • nucleolus • nucleoplasm • nucleus
Biological process	• cellular response to DNA damage stimulus • DNA replication • double-strand break repair via homologous recombination • nucleic acid phosphodiester bond hydrolysis • DNA repair • DNA-dependent DNA replication • interstrand cross-link repair • translesion synthesis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


353497


n/a

Ensembl


ENSG00000130997


n/a

UniProt


Q7Z5Q5


n/a

RefSeq (mRNA)


NM_181808


n/a

RefSeq (protein)


NP_861524.2


n/a

Location (UCSC)

Chr 4: 2.07 – 2.24 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Polymerase (DNA directed) nu is a protein in humans that is encoded by the POLN gene. ^[3] It is a family A DNA polymerase.^[4]

References

↑ "Diseases that are genetically associated with POLN view/edit references on wikidata".
↑ "Human PubMed Reference:".
↑ "Entrez Gene: Polymerase (DNA directed) nu". Retrieved 2012-05-03.
↑ Marini, F.; Kim, N; Schuffert, A; Wood, RD (4 June 2003). "POLN, a Nuclear PolA Family DNA Polymerase Homologous to the DNA Cross-link Sensitivity Protein Mus308". Journal of Biological Chemistry. 278 (34): 32014–32019. doi:10.1074/jbc.M305646200. PMID 12794064.

Zietlow, L.; Smith, L. A.; Bessho, M.; Bessho, T. (2009). "Evidence for the Involvement of Human DNA Polymerase N in the Repair of DNA Interstrand Cross-Links". Biochemistry. 48 (49): 11817–11824. doi:10.1021/bi9015346. PMC 2790558. PMID 19908865.
Bi, X.; Barkley, L. R.; Slater, D. M.; Tateishi, S.; Yamaizumi, M.; Ohmori, H.; Vaziri, C. (2006). "Rad18 Regulates DNA Polymerase and is Required for Recovery from S-Phase Checkpoint-Mediated Arrest". Molecular and Cellular Biology. 26 (9): 3527–3540. doi:10.1128/MCB.26.9.3527-3540.2006. PMC 1447421. PMID 16611994.
Moldovan, G. -L.; Madhavan, M. V.; Mirchandani, K. D.; McCaffrey, R. M.; Vinciguerra, P.; d'Andrea, A. D. (2009). "DNA Polymerase POLN Participates in Cross-Link Repair and Homologous Recombination". Molecular and Cellular Biology. 30 (4): 1088–1096. doi:10.1128/MCB.01124-09. PMC 2815579. PMID 19995904.
Marini, F.; Kim, N.; Schuffert, A.; Wood, R. D. (2003). "POLN, a Nuclear PolA Family DNA Polymerase Homologous to the DNA Cross-link Sensitivity Protein Mus308". Journal of Biological Chemistry. 278 (34): 32014–32019. doi:10.1074/jbc.M305646200. PMID 12794064.
Arana, M. E.; Takata, K. I.; Garcia-Diaz, M.; Wood, R. D.; Kunkel, T. A. (2007). "A unique error signature for human DNA polymerase ν". DNA Repair. 6 (2): 213–223. doi:10.1016/j.dnarep.2006.09.012. PMC 1950682. PMID 17118716.
Gohler, T.; Sabbioneda, S.; Green, C. M.; Lehmann, A. R. (2011). "ATR-mediated phosphorylation of DNA polymerase is needed for efficient recovery from UV damage". The Journal of Cell Biology. 192 (2): 219–227. doi:10.1083/jcb.201008076. PMC 3172178. PMID 21242293.
Yamanaka, K.; Minko, I. G.; Takata, K. I.; Kolbanovskiy, A.; Kozekov, I. D.; Wood, R. D.; Rizzo, C. J.; Lloyd, R. S. (2010). "Novel Enzymatic Function of DNA Polymerase ν in Translesion DNA Synthesis Past Major Groove DNA−Peptide and DNA−DNA Cross-Links". Chemical Research in Toxicology. 23 (3): 689–695. doi:10.1021/tx900449u. PMC 2838406. PMID 20102227.
Arana, M. E.; Potapova, O.; Kunkel, T. A.; Joyce, C. M. (2011). "Kinetic Analysis of the Unique Error Signature of Human DNA Polymerase ν". Biochemistry. 50 (46): 10126–10135. doi:10.1021/bi201197p. PMC 3235957. PMID 22008035.

This article is issued from Wikipedia - version of the 5/20/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

DNA polymerase nu

References

Further reading