DIS3

DIS3
Identifiers
Aliases	DIS3, 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
External IDs	MGI: 1919912 HomoloGene: 6910 GeneCards: DIS3
Gene ontology Molecular function • nuclease activity • hydrolase activity • guanyl-nucleotide exchange factor activity • exonuclease activity • RNA binding • protein binding • endonuclease activity • 3'-5'-exoribonuclease activity Cellular component • nucleolus • nucleoplasm • cytoplasm • exosome (RNase complex) • cytosol • nucleus • nuclear exosome (RNase complex) • membrane • cytoplasmic exosome (RNase complex) Biological process • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • regulation of mRNA stability • mRNA catabolic process • CUT catabolic process • rRNA processing • rRNA catabolic process • positive regulation of GTPase activity • nucleic acid phosphodiester bond hydrolysis • RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22894	72662
Ensembl	ENSG00000083520	ENSMUSG00000033166
UniProt	Q9Y2L1	Q9CSH3
RefSeq (mRNA)	NM_001128226 NM_014953 NM_001322348 NM_001322349	NM_028315
RefSeq (protein)	NP_001121698.1 NP_055768.3	NP_082591.2
Location (UCSC)	Chr 13: 72.75 – 72.78 Mb	Chr 14: 99.08 – 99.1 Mb
PubMed search	[1]	[2]
Wikidata

Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene.^[3][4] Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells.^[5][6]

References

Further reading