DBC1

Not to be confused with Deleted in Breast Cancer 1 (DBC1).
BRINP1
Identifiers
Aliases BRINP1, DBC1, DBCCR1, FAM5A, BMP/retinoic acid inducible neural specific 1
External IDs MGI: 1928478 HomoloGene: 8754 GeneCards: BRINP1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

1620

56710

Ensembl

ENSG00000078725

ENSMUSG00000028351

UniProt

O60477

Q920P3

RefSeq (mRNA)

NM_014618

NM_019967

RefSeq (protein)

NP_055433.2

NP_064351.2

Location (UCSC) Chr 9: 119.15 – 119.37 Mb Chr 4: 68.76 – 68.95 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.[3][4][5][6][7]

This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.[5]

The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Habuchi T, Yoshida O, Knowles MA (Jul 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
  4. Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.
  5. 1 2 "Entrez Gene: DBC1 deleted in bladder cancer 1".
  6. Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum. Mol. Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
  7. Nishiyama H, Hornigold N, Davies AM, Knowles MA (August 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.

Further reading


This article is issued from Wikipedia - version of the 6/6/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.