D-sedoheptulose 7-phosphate isomerase
D-sedoheptulose 7-phosphate isomerase | |||||||||
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Identifiers | |||||||||
EC number | 5.3.1.28 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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D-sedoheptulose 7-phosphate isomerase (EC 5.3.1.28, sedoheptulose-7-phosphate isomerase, phosphoheptose isomerase, gmhA (gene), lpcA (gene)) is an enzyme with systematic name D-glycero-D-manno-heptose 7-phosphate aldose-ketose-isomerase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- D-sedoheptulose 7-phosphate D-glycero-D-manno-heptose 7-phosphate
In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose.
References
- ↑ Kneidinger, B.; Marolda, C.; Graninger, M.; Zamyatina, A.; McArthur, F.; Kosma, P.; Valvano, M.A.; Messner, P. (2002). "Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli". J. Bacteriol. 184: 363–369. doi:10.1128/jb.184.2.363-369.2002. PMID 11751812.
- ↑ Kneidinger, B.; Graninger, M.; Puchberger, M.; Kosma, P.; Messner, P. (2001). "Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose". J. Biol. Chem. 276: 20935–20944. doi:10.1074/jbc.m100378200. PMID 11279237.
- ↑ Valvano, M.A.; Messner, P.; Kosma, P. (2002). "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides". Microbiology. 148: 1979–1989. doi:10.1099/00221287-148-7-1979. PMID 12101286.
- ↑ Kim, M.S.; Shin, D.H. (2009). "A preliminary X-ray study of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65: 1110–1112. doi:10.1107/s174430910903259x. PMID 19923728.
- ↑ Taylor, P.L.; Blakely, K.M.; de Leon, G.P.; Walker, J.R.; McArthur, F.; Evdokimova, E.; Zhang, K.; Valvano, M.A.; Wright, G.D.; Junop, M.S. (2008). "Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants". J. Biol. Chem. 283: 2835–2845. doi:10.1074/jbc.m706163200. PMID 18056714.
External links
- D-sedoheptulose 7-phosphate isomerase at the US National Library of Medicine Medical Subject Headings (MeSH)
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