Crc (protein)

Crc

Crystal structure of Crc in Pseudomonas aeruginosa.[1]
Identifiers
Symbol Crc
Pfam PF03372
CDD cd08372

The Catabolite repression control (Crc) protein participates in suppressing expression of several genes involved in utilization of carbon sources in Pseudomonas bacteria. Presence of organic acids triggers activation of Crc and in conjunction with the Hfq protein genes that metabolize a given carbon source are downregulated until another more favorable carbon source is depleted.[2] Crc-mediated regulation impact processes such as biofilm formation,[3] virulence [4] and antibiotic susceptibility.[5]

Interactions

A consensus sequence targeted by Crc mediated regulation

Hfq and Crc bind to A-rich sequences in the ribosome binding sites of genes that code for carbon utilization enzymes and consequently suppress their translation.[6]

References

  1. ↑ Wei, Y; Zhang, H; Gao, Z.-Q.; Xu, J.-H; Liu, Q.-S; Dong, Y.-H (2013). "Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginosa.". IUBMB Life. 65 (1): 50–57. doi:10.1002/iub.1103.
  2. ↑ Sonnleitner, E; Bläsi, U (2014). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa Carbon Catabolite Repression.". PLOS Genetics. 10 (6): e1004440. doi:10.1371/journal.pgen.1004440. PMC 4063720Freely accessible. PMID 24945892.
  3. ↑ O'Toole, GA; Gibbs, KA; Hager, PW; Phibbs, PV jr; Kolter, R (2000). "The global carbon metabolism regulator Crc is a component of a signal transduction pathway required for biofilm development by Pseudomonas aeruginosa.". J Bacteriol. 182: 425–431. doi:10.1128/jb.182.2.425-431.2000.
  4. ↑ Zhang, L; Chiang, WC; Gao, Q; Givskov, M; Tolker-Nielsen, T; et al. (2012). "The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms.". Microbiology. 158: 3014–3019. doi:10.1099/mic.0.061192-0.
  5. ↑ Yeung, AT; Bains, M; Hancock, RE (2011). "The sensor kinase CbrA is a global regulator that modulates metabolism, virulence, and antibiotic resistance in Pseudomonas aeruginosa.". J Bacteriol. 193: 918–931. doi:10.1128/jb.00911-10.
  6. ↑ Sonnleitner, E; Bläsi, U (2014). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa Carbon Catabolite Repression.". PLOS Genetics. 10 (6): e1004440. doi:10.1371/journal.pgen.1004440. PMC 4063720Freely accessible. PMID 24945892.
This article is issued from Wikipedia - version of the 11/11/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.