Convergent synthesis
In chemistry a convergent synthesis is a strategy that aims to improve the efficiency of multistep synthesis, most often in organic synthesis. In this type of synthesis several individual pieces of a complex molecule are synthesized in stage one and then in stage two these pieces are combined to form the final product [1] In linear synthesis the overall yield quickly drops with each reaction step:
- A → B → C → D
Suppose the yield is 50% for each reaction, the overall yield of D is only 12.5% from A.
In a convergent synthesis
- A → B (50%)
- C → D (50%)
- B + D → E (25%)
the overall yield of E (25%) looks much better. Convergent synthesis is applied in the synthesis of complex molecules and involve fragment coupling and independent synthesis.
Examples:
- Convergent synthesis is encountered in dendrimer synthesis [2] where branches (with the number of generations preset) are connected to the central core
- Proteins of up to 300 amino acids are produced by a convergent approach using chemical ligation.
- An example of its use in total synthesis is the final step (photochemical [2+2]cycloaddition) towards the compound Biyouyanagin A:[3]
See also
References
- ↑ Organic Synthesis, 3th Ed. 2010 Michael Smith
- ↑ Convergent Synthesis of Internally Branched PAMAM Dendrimers Michael Pittelkow, Jrn B. Christensen Org. Lett., 7 (7), 1295 -1298, 2005
- ↑ Total Synthesis and Revised Structure of Biyouyanagin A K. C. Nicolaou, David Sarlah, and David M. Shaw Angew. Chem. Int. Ed. 2007, 46, 4708 –4711 doi:10.1002/anie.200701552
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