Carglumic acid
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | Consumer Drug Information |
| License data | |
| Pregnancy category |
|
| Routes of administration | Oral |
| ATC code | A16AA05 (WHO) |
| Pharmacokinetic data | |
| Bioavailability | 30% |
| Protein binding | Undetermined |
| Metabolism | Partial |
| Biological half-life | 4.3 to 9.5 hours |
| Excretion | Fecal (60%) and renal (9%, unchanged) |
| Identifiers | |
| |
| Synonyms | (S)-2-ureidopentanedioic acid |
| CAS Number |
1188-38-1  |
| PubChem (CID) | 121396 |
| IUPHAR/BPS | 7458 |
| DrugBank |
DB06775  |
| ChemSpider |
1265942 108351 |
| UNII |
5L0HB4V1EW |
| KEGG |
D07130 |
| ChEBI |
CHEBI:71028 |
| ChEMBL |
CHEMBL1201780 |
| ECHA InfoCard | 100.116.323 |
| Chemical and physical data | |
| Formula | C6H10N2O5 |
| Molar mass | 190.2 g/mol |
| 3D model (Jmol) | Interactive image |
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| (what is this?) (verify) | |
Carglumic acid is an orphan drug, marketed by Orphan Europe under the trade name Carbaglu. Carglumic acid is used for the treatment of hyperammonaemia in patients with N-acetylglutamate synthase deficiency.[1][2] The initial daily dose ranges from 100 to 250 mg/kg, adjusted thereafter to maintain normal plasma levels of ammonia.
The US FDA approved it for treatment of hyperammonaemia on March 18, 2010. Orphan Drug exclusivity expires on March 18, 2017.[3]
Adverse effects
The most common adverse effects include vomiting, abdominal pain, fever, and tonsillitis.[4]
References
- ↑ Caldovic L, Morizono H, Daikhin Y, Nissim I, McCarter RJ, Yudkoff M, Tuchman M (2004). "Restoration of ureagenesis in N-acetylglutamate synthase deficiency by N-carbamylglutamate". J Pediatr. 145 (4): 552–4. doi:10.1016/j.jpeds.2004.06.047. PMID 15480384.
- ↑ Elpeleg O, Shaag A, Ben-Shalom E, Schmid T, Bachmann C (2002). "N-acetylglutamate synthase deficiency and the treatment of hyperammonemic encephalopathy". Ann Neurol. 52 (6): 845–9. doi:10.1002/ana.10406. PMID 12447942.
- ↑ "Patent and Exclusivity Search Results".
- ↑ Drugs.com: Professional Drug Facts for Carglumic Acid.
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