CPZ (gene)

CPZ
Identifiers
Aliases	CPZ
External IDs	MGI: 88487 HomoloGene: 2709 GeneCards: CPZ
Gene ontology Molecular function • carboxypeptidase activity • zinc ion binding • peptidase activity • hydrolase activity • metallopeptidase activity • metal ion binding • metallocarboxypeptidase activity • serine-type carboxypeptidase activity Cellular component • extracellular space • proteinaceous extracellular matrix • extracellular region • extracellular exosome Biological process • protein processing • Wnt signaling pathway • proteolysis • peptide metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8532	242939
Ensembl	ENSG00000109625	ENSMUSG00000036596
UniProt	Q66K79	Q8R4V4
RefSeq (mRNA)	NM_003652 NM_001014447 NM_001014448	NM_153107
RefSeq (protein)	NP_001014447.1 NP_001014448.1 NP_003643.2	NP_694747.2
Location (UCSC)	Chr 4: 8.59 – 8.62 Mb	Chr 5: 35.5 – 35.53 Mb
PubMed search	[1]	[2]
Wikidata

Carboxypeptidase Z is an enzyme that in humans is encoded by the CPZ gene.^[3][4]

This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.^[4]

References

Further reading