Calcineurin B homologous protein 1

CHP1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2E30

Identifiers

Aliases

CHP1, CHP, SLC9A1BP, Sid470p, p22, p24, calcineurin like EF-hand protein 1

External IDs

MGI: 1927185 HomoloGene: 5235 GeneCards: CHP1

Gene ontology
Molecular function	• calcium ion binding • transporter activity • microtubule binding • protein kinase inhibitor activity • metal ion binding • calcium-dependent protein binding • potassium channel regulator activity • kinase binding • protein binding
Cellular component	• cytoplasm • cytosol • membrane • focal adhesion • microtubule cytoskeleton • Golgi membrane • plasma membrane • transport vesicle • endoplasmic reticulum • extracellular exosome • cytoskeleton • endomembrane system • nucleus • endoplasmic reticulum-Golgi intermediate compartment
Biological process	• negative regulation of protein phosphorylation • positive regulation of protein glycosylation • negative regulation of calcineurin-NFAT signaling cascade • hyaluronan catabolic process • negative regulation of protein autophosphorylation • negative regulation of protein kinase activity • positive regulation of sodium:proton antiporter activity • negative regulation of phosphatase activity • small GTPase mediated signal transduction • protein stabilization • cellular response to acidic pH • membrane fusion • regulation of intracellular pH • positive regulation of protein transport • negative regulation of protein ubiquitination • potassium ion transport • protein oligomerization • microtubule bundle formation • cytoplasmic microtubule organization • protein export from nucleus • membrane docking • regulation of neuron death • transport • protein transport • membrane organization • negative regulation of NF-kappaB transcription factor activity • calcium ion regulated exocytosis • positive regulation of protein targeting to membrane • negative regulation of protein import into nucleus
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


11261


56398

Ensembl


ENSG00000187446


ENSMUSG00000014077

UniProt


Q99653


P61022

RefSeq (mRNA)


NM_007236


NM_019769

RefSeq (protein)


NP_009167.1


NP_062743.1

Location (UCSC)

Chr 15: 41.23 – 41.28 Mb

Chr 2: 119.55 – 119.59 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

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Calcineurin B homologous protein 1 is protein encoded in humans by the CHP1 gene (formerly CHP).^[3]

Function

The protein encoded by this gene is a phosphoprotein that binds to the sodium-hydrogen exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity.^[3]

Interactions

Calcineurin B homologous protein 1 has been shown to interact with

sodium-hydrogen antiporter 1,^[4]^[5]^[6]
sodium-hydrogen antiporter 3,^[4] and
sodium-hydrogen anti porter 9.^[7]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: CHP calcium binding protein P22".
1 2 Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (Feb 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biological & Pharmaceutical Bulletin. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672.
↑ Lin X, Barber DL (Oct 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
↑ Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". The Journal of Biological Chemistry. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
↑ Zhang-James Y, DasBanerjee T, Sagvolden T, Middleton FA, Faraone SV (Dec 2011). "SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder". American Journal of Medical Genetics Part B. 156B (7): 835–43. doi:10.1002/ajmg.b.31229. PMC 3168688. PMID 21858920.

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (Sep 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Barroso MR, Bernd KK, DeWitt ND, Chang A, Mills K, Sztul ES (Apr 1996). "A novel Ca2+-binding protein, p22, is required for constitutive membrane traffic". The Journal of Biological Chemistry. 271 (17): 10183–7. doi:10.1074/jbc.271.17.10183. PMID 8626580.
Lin X, Barber DL (Oct 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
Lin X, Sikkink RA, Rusnak F, Barber DL (Dec 1999). "Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein". The Journal of Biological Chemistry. 274 (51): 36125–31. doi:10.1074/jbc.274.51.36125. PMID 10593895.
Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". The Journal of Biological Chemistry. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
Matsumoto M, Miyake Y, Nagita M, Inoue H, Shitakubo D, Takemoto K, Ohtsuka C, Murakami H, Nakamura N, Kanazawa H (Aug 2001). "A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger". Journal of Biochemistry. 130 (2): 217–25. doi:10.1093/oxfordjournals.jbchem.a002975. PMID 11481038.
Nakamura N, Miyake Y, Matsushita M, Tanaka S, Inoue H, Kanazawa H (Sep 2002). "KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles". Journal of Biochemistry. 132 (3): 483–91. doi:10.1093/oxfordjournals.jbchem.a003246. PMID 12204119.
Pang T, Wakabayashi S, Shigekawa M (Nov 2002). "Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger". The Journal of Biological Chemistry. 277 (46): 43771–7. doi:10.1074/jbc.M208313200. PMID 12226101.
Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (Feb 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biological & Pharmaceutical Bulletin. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672.
Pang T, Hisamitsu T, Mori H, Shigekawa M, Wakabayashi S (Mar 2004). "Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elements". Biochemistry. 43 (12): 3628–36. doi:10.1021/bi0360004. PMID 15035633.
Andrade J, Pearce ST, Zhao H, Barroso M (Dec 2004). "Interactions among p22, glyceraldehyde-3-phosphate dehydrogenase and microtubules". The Biochemical Journal. 384 (Pt 2): 327–36. doi:10.1042/BJ20040622. PMC 1134116. PMID 15312048.
Ben Ammar Y, Takeda S, Sugawara M, Miyano M, Mori H, Wakabayashi S (Oct 2005). "Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1". Acta Crystallographica Section F. 61 (Pt 10): 956–8. doi:10.1107/S1744309105030836. PMC 1991313. PMID 16511206.
Mishima M, Wakabayashi S, Kojima C (Jan 2007). "Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1". The Journal of Biological Chemistry. 282 (4): 2741–51. doi:10.1074/jbc.M604092200. PMID 17050540.

PDB gallery

2ct9: The crystal structure of calcineurin B homologous proein 1 (CHP1)

2e30: Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1

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Calcineurin B homologous protein 1

Function

Interactions

References

Further reading