CCNF
- CCNF may also mean Canonical conjunctive normal form in Boolean algebra.
G2/mitotic-specific cyclin-F is a protein that in humans is encoded by the CCNF gene.[3][4]
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.[4]
References
Further reading
- Nehls M, Lüno K, Schorpp M, et al. (1995). "YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4-cM interval on mouse chromosome 11.". Mamm. Genome. 6 (5): 321–31. doi:10.1007/BF00364794. PMID 7626882.
- Bai C, Richman R, Elledge SJ (1995). "Human cyclin F". EMBO J. 13 (24): 6087–98. PMC 395587
. PMID 7813445.
- Bai C, Sen P, Hofmann K, et al. (1996). "SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box". Cell. 86 (2): 263–74. doi:10.1016/S0092-8674(00)80098-7. PMID 8706131.
- Kong M, Barnes EA, Ollendorff V, Donoghue DJ (2000). "Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin–cyclin interaction". EMBO J. 19 (6): 1378–88. doi:10.1093/emboj/19.6.1378. PMC 305678. PMID 10716937.
- Fung TK, Siu WY, Yam CH, et al. (2002). "Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins". J. Biol. Chem. 277 (38): 35140–9. doi:10.1074/jbc.M205503200. PMID 12122006.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
