C-terminal processing peptidase
| C-terminal processing peptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.102 | ||||||||
| CAS number | 92480-11-0&title= 216484-75-2, 92480-11-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
C-terminal processing peptidase (EC 3.4.21.102, CtpA gene product (Synechocystis sp.), photosystem II D1 protein processing peptidase, protease Re, tail-specific protease, Tsp protease) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- The enzyme shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala!Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala. In the plant chloroplast, the enzyme removes the C-terminal extension of the D1 polypeptide of photosystem II
Proteolytic processing of the D1 protein of photosystem II anables light-driven assembly of the tetranuclear manganese cluster.
References
- ↑ Keiler, K.C.; Sauer, R.T. (1998). "Tsp protease". In Barrett, A.J.; Rawlings, N.D.; Woessner, J.F. Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. pp. 460–461.
- ↑ Beebe, K.D.; Shin, J.N.; Peng, J.; Chaudhury, C.; Khera, J.; Pei, D.H. (2000). "Substrate recognition through a PDZ domain in tail-specific protease". Biochemistry. 39 (11): 3149–3155. doi:10.1021/bi992709s. PMID 10715137.
- ↑ Liao, D.I.; Qian, J.; Chisholm, D.A.; Jordan, D.B.; Diner, B.A. (2000). "Crystal structures of the photosystem II D1 C-terminal processing protease". Nat. Struct. Biol. 7 (9): 749–753. doi:10.1038/78973. PMID 10966643.
External links
- C-terminal processing peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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