Brachyurin
| Brachyurin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.32 | ||||||||
| CAS number | 848900-32-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Brachyurin (EC 3.4.21.32, Uca pugilator collagenolytic proteinase, crab protease I, crab protease II) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- Hydrolysis of proteins, with broad specificity for peptide bonds. Native collagen is cleaved about 75% of the length of the molecule from the N-terminus.
This enzyme is isolated from hepatopancreas of the fiddler crab, Uca pugilator.
References
- ↑ Hurion, N.; Fromentin, H.; Keil, B. (1979). "Specificity of the collagenolytic enzyme from the fungus Entomophthora coronata: comparison with the bacterial collagenase from Achromobacter iophagus". Arch. Biochem. Biophys. 192: 438–445. doi:10.1016/0003-9861(79)90113-9. PMID 219780.
- ↑ Grant, G.A.; Eisen, A.Z.; Bradshaw, R.A. (1981). "Collagenolytic protease from fiddler crab (Uca pugilator)". Methods Enzymol. 80: 722–734. doi:10.1016/s0076-6879(81)80055-9.
- ↑ Welgus, H.G.; Grant, G.A.; Jeffrey, J.J.; Eisen, A.Z. (1982). "Substrate specificity of the collagenolytic serine protease from Uca pugilator: studies with collagenous substrates". Biochemistry. 21: 5183–5189. doi:10.1021/bi00264a012. PMID 6756469.
- ↑ Welgus, H.G.; Grant, G.A. (1983). "Degradation of collagen substrates by a trypsin-like serine protease form the fiddler crab Uca pugilator". Biochemistry. 22: 2228–2233. doi:10.1021/bi00278a026. PMID 6305411.
- ↑ Klimova, O.A.; Borukhov, S.I.; Solovyeva, N.I.; Balaevskaya, T.O.; Strongin, A.Y. (1990). "The isolation and properties of collagenolytic proteases from crab hepatopancreas". Biochem. Biophys. Res. Commun. 166: 1411–1420. doi:10.1016/0006-291x(90)91024-m. PMID 2154979.
- ↑ Lu, P.-J.; Liu, H.-C.; Tsai, I.-H. (1990). "The midgut trypsins of shrimp (Penaeus monodon). High efficiency toward native protein substrates including collagens". Biol. Chem. Hoppe-Seyler. 371: 851–859. doi:10.1515/bchm3.1990.371.2.851. PMID 1963309.
External links
- Brachyurin at the US National Library of Medicine Medical Subject Headings (MeSH)
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