Blasticidin-S deaminase
blasticidin-S deaminase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC number | 3.5.4.23 | ||||||||
CAS number | 54576-55-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
|
In enzymology, a blasticidin-S deaminase (EC 3.5.4.23) is an enzyme that catalyzes the chemical reaction
- blasticidin S + H2O deaminohydroxyblasticidin S + NH3
Thus, the two substrates of this enzyme are blasticidin S and H2O, whereas its two products are deaminohydroxyblasticidin S and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is blasticidin-S aminohydrolase.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WN5 and 1WN6.
References
- Yamaguchi I, Shibata H, Seto H, Misato T. "Isolation and purification of blasticidin S deaminase from Aspergillus terreus". J. Tokyo. Antibiot. (1): 7–14. PMID 236272.
This article is issued from Wikipedia - version of the 8/10/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.