Blasticidin-S deaminase

blasticidin-S deaminase
Identifiers
EC number 3.5.4.23
CAS number 54576-55-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a blasticidin-S deaminase (EC 3.5.4.23) is an enzyme that catalyzes the chemical reaction

blasticidin S + H2O deaminohydroxyblasticidin S + NH3

Thus, the two substrates of this enzyme are blasticidin S and H2O, whereas its two products are deaminohydroxyblasticidin S and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is blasticidin-S aminohydrolase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WN5 and 1WN6.

References


    This article is issued from Wikipedia - version of the 8/10/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.