Ap4A

Diadenosine tetraphosphate or Ap4A is a putative alarmone, ubiquitous in nature being common to everything from bacteria to humans. Adenosine polyphosphates are capable of inducing multiple physiological effects.[1] The molecule's role as a second messenger has recently been discovered in The LysRS-Ap4A-MITF signaling pathway.[2]

References

  1. ↑
    • Luo J, Jankowski V, Güngär N, Neumann J, Schmitz W, Zidek W, Schlüter H, Jankowski J (2004). "Endogenous diadenosine tetraphosphate, diadenosine pentaphosphate, and diadenosine hexaphosphate in human myocardial tissue.". Hypertension. 43 (5): 1055–9. doi:10.1161/01.hyp.0000126110.46402.dd. PMID 15066958.
  2. ↑
    • Lee YN, Nechushtan H, Figov N, Razin E (April 2004). "The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells.". Immunity. 20 (2): 145–51. doi:10.1016/S1074-7613(04)00020-2. PMID 14975237.


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