Aminopyrimidine aminohydrolase
| Aminopyrimidine aminohydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.5.99.2 | ||||||||
| CAS number | 9024-80-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Aminopyrimidine aminohydrolase (EC 3.5.99.2, thiaminase, thiaminase II, tenA (gene)) is an enzyme with systematic name 4-amino-5-aminomethyl-2-methylpyrimidine aminohydrolase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- (1) 4-amino-5-aminomethyl-2-methylpyrimidine + H2O 4-amino-5-hydroxymethyl-2-methylpyrimidine + ammonia
- (2) thiamine + H2O 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole
This enzyme was previously known as thiaminase II.
References
- ↑ Fujita, A.; Nose, Y.; Kuratani, K. (1954). "Second type of bacterial thiaminase". J. Vitaminol. (Kyoto). 1 (1): 1–7. doi:10.5925/jnsv1954.1.1. PMID 13243520.
- ↑ Ikehata, H. (1960). "Purification of thiaminase II". J. Gen. Appl. Microbiol. 6: 30–39. doi:10.2323/jgam.6.30.
- ↑ Toms, A.V.; Haas, A.L.; Park, J.H.; Begley, T.P.; Ealick, S.E. (2005). "Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II". Biochemistry. 44: 2319–2329. doi:10.1021/bi0478648. PMID 15709744.
- ↑ Benach, J.; Edstrom, W.C.; Lee, I.; Das, K.; Cooper, B.; Xiao, R.; Liu, J.; Rost, B.; Acton, T.B.; Montelione, G.T.; Hunt, J.F. (2005). "The 2.35 Å structure of the TenA homolog from Pyrococcus furiosus supports an enzymatic function in thiamine metabolism". Acta Crystallogr. D. 61 (Pt 5): 589–598. doi:10.1107/S0907444905005147. PMID 15858269.
- ↑ Jenkins, A.H.; Schyns, G.; Potot, S.; Sun, G.; Begley, T.P. (2007). "A new thiamin salvage pathway". Nat. Chem. Biol. 3 (8): 492–497. doi:10.1038/nchembio.2007.13. PMID 17618314.
- ↑ Jenkins, A.L.; Zhang, Y.; Ealick, S.E.; Begley, T.P. (2008). "Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis". Bioorg. Chem. 36 (1): 29–32. doi:10.1016/j.bioorg.2007.10.005. PMID 18054064.
- ↑ French, J.B.; Begley, T.P.; Ealick, S.E. (2011). "Structure of trifunctional THI20 from yeast". Acta Crystallogr. D. 67 (Pt 9): 784–791. doi:10.1107/S0907444911024814. PMID 21904031.
External links
- Aminopyrimidine aminohydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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