Aminopeptidase S
| Aminopeptidase S | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.11.24 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Aminopeptidase S (EC 3.4.11.24, Mername-AA022 peptidase, SGAP, aminopeptidase (Streptomyces griseus), Streptomyces griseus aminopeptidase, S. griseus AP, double-zinc aminopeptidase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Release of an N-terminal amino acid with a preference for large hydrophobic amino-terminus residues
This enzyme contains two zinc molecules in its active site and is activated by Ca2+.
References
- ↑ Spungin, A.; Blumberg, S. (1989). "Streptomyces griseus aminopeptidase is a calcium-activated zinc metalloprotein. Purification and properties of the enzyme". Eur. J. Biochem. 183: 471–477. doi:10.1111/j.1432-1033.1989.tb14952.x. PMID 2503378.
- ↑ Ben-Meir, D.; Spungin, A.; Ashkenazi, R.; Blumberg, S. (1993). "Specificity of Streptomyces griseus aminopeptidase and modulation of activity by divalent metal ion binding and substitution". Eur. J. Biochem. 212: 107–112. doi:10.1111/j.1432-1033.1993.tb17639.x. PMID 8444149.
- ↑ Arima, J.; Uesugi, Y.; Iwabuchi, M.; Hatanaka, T. (2006). "Study on peptide hydrolysis by aminopeptidases from Streptomyces griseus, Streptomyces septatus and Aeromonas proteolytica". Appl. Microbiol. Biotechnol. 70: 541–547. doi:10.1007/s00253-005-0105-8. PMID 16080009.
- ↑ Fundoiano-Hershcovitz, Y.; Rabinovitch, L.; Langut, Y.; Reiland, V.; Shoham, G.; Shoham, Y. (2004). "Identification of the catalytic residues in the double-zinc aminopeptidase from Streptomyces griseus". FEBS Lett. 571: 192–196. doi:10.1016/j.febslet.2004.07.001. PMID 15280041.
- ↑ Gilboa, R.; Greenblatt, H.M.; Perach, M.; Spungin-Bialik, A.; Lessel, U.; Wohlfahrt, G.; Schomburg, D.; Blumberg, S.; Shoham, G. (2000). "Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 Å resolution". Acta Crystallogr. D. 56: 551–558. doi:10.1107/s0907444900002420. PMID 10771423.
External links
- Aminopeptidase S at the US National Library of Medicine Medical Subject Headings (MeSH)
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