Aminometradine

Aminometradine
Clinical data

ATC code	none
Identifiers
IUPAC name 6-Amino-3-ethyl-1-prop-2-enylpyrimidine-2,4-dione
CAS Number	642-44-4
PubChem (CID)	12551
ChemSpider	12033^Y
UNII	PPM8SX5Q3V^Y
Chemical and physical data
Formula	C₉H₁₃N₃O₂
Molar mass	195.22 g/mol
3D model (Jmol)	Interactive image
SMILES O=C1N(/C(=C\C(=O)N1CC)N)C\C=C
InChI InChI=1S/C9H13N3O2/c1-3-5-12-7(10)6-8(13)11(4-2)9(12)14/h3,6H,1,4-5,10H2,2H3^Y Key:NGXUUAFYUCOICP-UHFFFAOYSA-N^Y
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Aminometradine is a weak diuretic which was used to control oedema in those who suffered mild congestive heart failure.

Alkyl uracil derivatives have been known for some time to act as diuretic agents in experimental animals. The toxicity of these agents precluded their use in the clinic. Appropriate modification of the molecule, did, however yield diuretic agents in man.

References

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