Aldos-2-ulose dehydratase
| Aldos-2-ulose dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.110 | ||||||||
| CAS number | 101920-80-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Aldos-2-ulose dehydratase (EC 4.2.1.110, pyranosone dehydratase, AUDH, 1,5-anhydro-D-fructose dehydratase (microthecin-forming)) is an enzyme with systematic name 1,5-anhydro-D-fructose hydro-lyase (microthecin-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- 1,5-anhydro-D-fructose 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O (overall reaction)
- (1a) 1,5-anhydro-D-fructose 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O
- (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one
This enzyme catalyses two of the steps in the anhydrofructose pathway.
References
- ↑ Yu, S.; Fiskesund, R. (2006). "The anhydrofructose pathway and its possible role in stress response and signaling". Biochim. Biophys. Acta. 1760: 1314–1322. doi:10.1016/j.bbagen.2006.05.007. PMID 16822618.
- ↑ Yu, S. (2005). "Enzymatic description of the anhydrofructose pathway of glycogen degradation. II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate". Biochim. Biophys. Acta. 1723: 63–73. doi:10.1016/j.bbagen.2005.01.004. PMID 15716041.
- ↑ Broberg, A.; Kenne, L.; Pedersén, M. (1996). "Presence of microthecin in the red alga Gracilariopsis lemaneiformis and its formation from 1,5-anhydro-D-fructose". Phytochemistry. 41: 151–154. doi:10.1016/0031-9422(95)00587-0.
- ↑ Gabriel, J.; Volc, J.; Sedmera, P.; Daniel, G.; Kubátová, E. (1993). "Pyranosone dehydratase from the basidiomycete Phanerochaete chrysosporium: improved purification, and identification of 6-deoxy-D-glucosone and D-xylosone reaction products". Arch. Microbiol. 160 (1): 27–34. doi:10.1007/BF00258142. PMID 8352649.
- ↑ Yu, S.; Refdahl, C.; Lundt, I. (2004). "Enzymatic description of the anhydrofructose pathway of glycogen degradation; I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and α-1,4-glucan lyase in the fungus Anthracobia melaloma". Biochim. Biophys. Acta. 1672: 120–129. doi:10.1016/j.bbagen.2004.03.004. PMID 15110094.
External links
- Aldos-2-ulose dehydratase at the US National Library of Medicine Medical Subject Headings (MeSH)
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