Acylcarnitine hydrolase
| acylcarnitine hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.1.28 | ||||||||
| CAS number | 37278-42-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, an acylcarnitine hydrolase (EC 3.1.1.28) is an enzyme that catalyzes the chemical reaction
- O-acylcarnitine + H2O a fatty acid + L-carnitine
Thus, the two substrates of this enzyme are O-acylcarnitine and H2O, whereas its two products are fatty acid and L-carnitine.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is O-acylcarnitine acylhydrolase. Other names in common use include high activity acylcarnitine hydrolase, HACH, carnitine ester hydrolase, palmitoylcarnitine hydrolase, palmitoyl-L-carnitine hydrolase, long-chain acyl-L-carnitine hydrolase, and palmitoyl carnitine hydrolase.
References
- Mahadevan S, Sauer F (1969). "Carnitine ester hydrolase of rat liver". J. Biol. Chem. 244 (16): 4448–53. PMID 5806585.
- Mentlein R, Reuter G, Heymann E (1985). "Specificity of two different purified acylcarnitine hydrolases from rat liver, their identity with other carboxylesterases, and their possible function". Arch. Biochem. Biophys. 240 (2): 801–10. doi:10.1016/0003-9861(85)90089-X. PMID 4026306.
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