APOBEC4

APOBEC4
Identifiers
Aliases APOBEC4, C1orf169, apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
External IDs MGI: 1918531 HomoloGene: 52415 GeneCards: APOBEC4
Orthologs
Species Human Mouse
Entrez

403314

71281

Ensembl

ENSG00000173627

ENSMUSG00000055547

UniProt

Q8WW27

Q497M3

RefSeq (mRNA)

NM_203454

NM_001081197

RefSeq (protein)

NP_982279.1

n/a

Location (UCSC) Chr 1: 183.65 – 183.65 Mb Chr 1: 152.75 – 152.76 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

C->U-editing enzyme APOBEC-4, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4, is a protein that in humans is encoded by the APOBEC4 gene. It is primarily expressed in testis and found in mammals, chicken, but not fishes.[3][4]

Function

This gene encodes a member of the AID / APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection.[4]

A recent study on APOBEC4 (A4) revealed an interesting finding that A4 enhanced the replication of HIV-1 through boosting promoter activity, it also increased the expression of other relevant promoter mediated enhanced protein expression. Biochemical analysis of A4 showed the lack of cytidine deaminase activity on single stranded DNA and it binds DNA rather weak.[5]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Rogozin IB, Basu MK, Jordan IK, Pavlov YI, Koonin EV (September 2005). "APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis". Cell Cycle. 4 (9): 1281–5. doi:10.4161/cc.4.9.1994. PMID 16082223.
  4. 1 2 "Entrez Gene: apolipoprotein B mRNA editing enzyme".
  5. ↑ Marino D, Perković M, Hain A, Jaguva Vasudevan AA, Hofmann H, Hanschmann KM, Mühlebach MD, Schumann GG, König R, Cichutek K, Häussinger D, Münk C (2016). "APOBEC4 Enhances the Replication of HIV-1". PloS One. 11 (6): e0155422. doi:10.1371/journal.pone.0155422. PMID 27249646.

Further reading

  • Prochnow C, Bransteitter R, Chen XS (October 2009). "APOBEC deaminases-mutases with defensive roles for immunity". Science in China. Series C, Life Sciences / Chinese Academy of Sciences. 52 (10): 893–902. doi:10.1007/s11427-009-0133-1. PMID 19911124. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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