APBA3

APBA3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases APBA3, MGC:15815, X11L2, mint3, amyloid beta precursor protein binding family A member 3
External IDs MGI: 1888527 HomoloGene: 3591 GeneCards: APBA3
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

9546

57267

Ensembl

ENSG00000011132

ENSMUSG00000004931

UniProt

O96018

O88888

RefSeq (mRNA)

NM_004886

NM_018758

RefSeq (protein)

NP_004877.1

NP_061228.1

Location (UCSC) Chr 19: 3.75 – 3.76 Mb Chr 10: 81.27 – 81.27 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Amyloid beta A4 precursor protein-binding family A member 3 is a protein that in humans is encoded by the APBA3 gene.[3][4]

Function

The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.[4]

Interactions

APBA3 has been shown to interact with Amyloid precursor protein.[3][5]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. 1 2 Tanahashi H, Tabira T (Apr 1999). "X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein". Biochem Biophys Res Commun. 255 (3): 663–7. doi:10.1006/bbrc.1999.0265. PMID 10049767.
  4. 1 2 "Entrez Gene: APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2)".
  5. ↑ Biederer T, Cao X, Südhof TC, Liu X (Sep 2002). "Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms". J. Neurosci. 22 (17): 7340–51. PMID 12196555.

Further reading

  • Kuriyan J, Cowburn D (1997). "Modular peptide recognition domains in eukaryotic signaling". Annual Review of Biophysics and Biomolecular Structure. 26: 259–88. doi:10.1146/annurev.biophys.26.1.259. PMID 9241420. 
  • Morishima-Kawashima M, Ihara Y (2002). "[Recent advances in Alzheimer's disease]". Seikagaku. 73 (11): 1297–307. PMID 11831025. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Okamoto M, Südhof TC (1999). "Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2". Eur. J. Cell Biol. 77 (3): 161–5. doi:10.1016/s0171-9335(98)80103-9. PMID 9860131. 
  • Tanahashi H, Tabira T (1999). "Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein". NeuroReport. 10 (12): 2575–8. doi:10.1097/00001756-199908200-00025. PMID 10574372. 
  • Okamoto M, Nakajima Y, Matsuyama T, Sugita M (2001). "Amyloid precursor protein associates independently and collaboratively with PTB and PDZ domains of mint on vesicles and at cell membrane". Neuroscience. 104 (3): 653–65. doi:10.1016/S0306-4522(01)00124-5. PMID 11440799. 
  • Wang P, Wang X, Pei D (2004). "Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV". J. Biol. Chem. 279 (19): 20461–70. doi:10.1074/jbc.M400264200. PMID 14990567. 
  • Malmberg EK, Andersson CX, Gentzsch M, Chen JH, Mengos A, Cui L, Hansson GC, Riordan JR (2005). "Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3". J. Cell. Sci. 117 (Pt 23): 5535–41. doi:10.1242/jcs.01472. PMID 15494376. 


This article is issued from Wikipedia - version of the 5/19/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.