AMP nucleosidase

AMP nucleosidase
Identifiers
EC number 3.2.2.4
CAS number 9025-45-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an AMP nucleosidase (EC 3.2.2.4) is an enzyme that catalyzes the chemical reaction

AMP + H2O D-ribose 5-phosphate + adenine

Thus, the two substrates of this enzyme are AMP and H2O, whereas its two products are D-ribose 5-phosphate and adenine.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is AMP phosphoribohydrolase. Other names in common use include adenylate nucleosidase, and adenosine monophosphate nucleosidase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1T8R, 1T8S, 1T8W, 1T8Y, and 2GUW.

References


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