ACYP1
Acylphosphatase-1 is an enzyme that in humans is encoded by the ACYP1 gene.[3][4][5]
Function
Acylphosphatase is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase, on the basis of their tissue localization. This gene encodes the erythrocyte acylphosphatase isoenzyme. Alternatively spliced transcript variants that encode different proteins were identified through data analysis.[5]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Fiaschi T, Raugei G, Marzocchini R, Chiarugi P, Cirri P, Ramponi G (Jun 1995). "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase". FEBS Letters. 367 (2): 145–8. doi:10.1016/0014-5793(95)00553-L. PMID 7796909.
- ↑ Fiaschi T, Marzella R, Veggi D, Marzocchini R, Raugei G, Rocchi M, Ramponi G (Oct 1998). "Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to chromosome band 14q24.3". Cytogenetics and Cell Genetics. 81 (3-4): 235–6. doi:10.1159/000015037. PMID 9730610.
- 1 2 "Entrez Gene: ACYP1 acylphosphatase 1, erythrocyte (common) type".
External links
Further reading
- Nassi P, Nediani C, Liguri G, Taddei N, Ramponi G (Jun 1991). "Effects of acylphosphatase on the activity of erythrocyte membrane Ca2+ pump". The Journal of Biological Chemistry. 266 (17): 10867–71. PMID 1645713.
- Degl'Innocenti D, Berti A, Stefani M, Liguri G, Ramponi G (Aug 1990). "Immunoaffinity purification and immunoassay determination of human erythrocyte acylphosphatase". Biotechnology and Applied Biochemistry. 12 (4): 450–9. PMID 2169259.
- Liguri G, Camici G, Manao G, Cappugi G, Nassi P, Modesti A, Ramponi G (Dec 1986). "A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure". Biochemistry. 25 (24): 8089–94. doi:10.1021/bi00372a044. PMID 3026468.
- Paoli P, Pazzagli L, Giannoni E, Caselli A, Manao G, Camici G, Ramponi G (Jan 2003). "A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase". The Journal of Biological Chemistry. 278 (1): 194–9. doi:10.1074/jbc.M206918200. PMID 12409302.
- Degl'Innocenti D, Marzocchini R, Malentacchi F, Ramazzotti M, Raugei G, Ramponi G (Jan 2004). "ACYP1 gene possesses two alternative splicing forms that induce apoptosis". IUBMB Life. 56 (1): 29–33. doi:10.1080/15216540310001654349. PMID 14992377.
