8-oxo-dGDP phosphatase
| 8-oxo-dGDP phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.6.1.58 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
8-oxo-dGDP phosphatase (EC 3.6.1.58, NUDT5) is an enzyme with systematic name 8-oxo-dGDP phosphohydrolase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- 8-oxo-dGDP + H2O 8-oxo-dGMP + phosphate
The enzyme catalyses the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP.
References
- ↑ Ishibashi, T.; Hayakawa, H.; Ito, R.; Miyazawa, M.; Yamagata, Y.; Sekiguchi, M. (2005). "Mammalian enzymes for preventing transcriptional errors caused by oxidative damage". Nucleic Acids Res. 33: 3779–3784. doi:10.1093/nar/gki682. PMID 16002790.
- ↑ Ishibashi, T.; Hayakawa, H.; Sekiguchi, M. (2003). "A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides". EMBO Rep. 4 (5): 479–483. doi:10.1038/sj.embor.embor838. PMC 1319193
. PMID 12717453. - ↑ Kamiya, H.; Hori, M.; Arimori, T.; Sekiguchi, M.; Yamagata, Y.; Harashima, H. (2009). "NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity". DNA Repair (Amst). 8 (10): 1250–1254. doi:10.1016/j.dnarep.2009.07.011. PMID 19699693.
- ↑ Ito, R.; Sekiguchi, M.; Setoyama, D.; Nakatsu, Y.; Yamagata, Y.; Hayakawa, H. (2011). "Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein". J. Biochem. 149 (6): 731–738. doi:10.1093/jb/mvr028. PMID 21389046.
- ↑ Zha, M.; Zhong, C.; Peng, Y.; Hu, H.; Ding, J. (2006). "Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity". J. Mol. Biol. 364 (5): 1021–1033. doi:10.1016/j.jmb.2006.09.078. PMID 17052728.
External links
- 8-oxo-dGDP phosphatase at the US National Library of Medicine Medical Subject Headings (MeSH)
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