5-Histidylcysteine sulfoxide synthase

5-Histidylcysteine sulfoxide synthase is the first enzyme in the biosynthesis of ovothiol, catalyzing the oxidative addition of cysteine to histidine, forming 5-histidylcysteine sulfoxide.[1] The enzyme is found in Trypanosomes, where it additionally has a SAM dependent methyl transferase, which adds a methyl group to N1.

References

  1. ↑ Braunshausen, A. & Seebeck, F. P. Identification and characterization of the first ovothiol biosynthetic enzyme. J. Am. Chem. Soc. 133, 1757-1759 (2011).
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