5-Fluoro-5-deoxy-D-ribose-1-phosphate
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| Names | |
|---|---|
| IUPAC name
5-Deoxy-5-fluoro-1-O-phosphonato-D-ribofuranose | |
| Identifiers | |
| 3D model (Jmol) | Interactive image |
| ChemSpider | 21169315 (dianion) |
| PubChem | 49859615 (dianion) |
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| Properties | |
| C5H10FO7P | |
| Molar mass | 232.10 g·mol−1 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
5-Fluoro-5-deoxy-D-ribose-1-phosphate is metabolite formed during the biosynthesis of organofluorides. It is formed by the purine nucleoside phosphorylase mediated phosphorolytic cleavage of 5'-deoxy-5'-fluoroadenosine.[1] It is isomerized to 5-fluoro-5-deoxy-ribulose-1-phosphate which is then cleaved by an aldolase to release fluoroacetaldehyde.[2]
References
- ↑ O'Hagan D; Schaffrath C; Cobb SL; Hamilton JT; Murphy CD (2002). "Biochemistry: biosynthesis of an organofluorine molecule". Nature. 416 (6878): 279. doi:10.1038/416279a. PMID 11907567.
- ↑ Hai Deng; Stuart M. Cross; Ryan P. McGlinchey; John T.G. Hamilton; David O'Hagan (2008). "In Vitro Reconstituted Biotransformation of 4-Fluorothreonine from Fluoride Ion: Application of the Fluorinase". Chemistry and Biology. 15 (12): 1268–1276. doi:10.1016/j.chembiol.2008.10.012. PMID 19101471.
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