4-methyleneglutamate—ammonia ligase
| 4-methyleneglutamate-ammonia ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 6.3.1.7 | ||||||||
| CAS number | 85537-85-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, a 4-methyleneglutamate—ammonia ligase (EC 6.3.1.7) is an enzyme that catalyzes the chemical reaction
- ATP + 4-methylene-L-glutamate + NH3 AMP + diphosphate + 4-methylene-L-glutamine
The 3 substrates of this enzyme are ATP, 4-methylene-L-glutamate, and NH3, whereas its 3 products are AMP, diphosphate, and 4-methylene-L-glutamine.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is 4-methylene-L-glutamate:ammonia ligase (AMP-forming). This enzyme is also called 4-methyleneglutamine synthetase. This enzyme participates in c5-branched dibasic acid metabolism.
References
- Winter HC, Su TZ, Dekker EE (1983). "4-methyleneglutamine synthetase: a new amide synthetase present in germinating peanuts". Biochem. Biophys. Res. Commun. 111 (2): 484–9. doi:10.1016/0006-291X(83)90332-7. PMID 6838571.
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