4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
| 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.7.1.17 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase (EC 3.7.1.17, tesD (gene), hsaD (gene)) is an enzyme with systematic name 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase ( (2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction
- (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate
The enzyme is involved in the bacterial degradation of the steroid ring structure.
References
- ↑ Horinouchi, M.; Hayashi, T.; Koshino, H.; Kurita, T.; Kudo, T. (2005). "Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441". Appl. Environ. Microbiol. 71: 5275–5281. doi:10.1128/aem.71.9.5275-5281.2005. PMID 16151114.
- ↑ Van der Geize, R.; Yam, K.; Heuser, T.; Wilbrink, M.H.; Hara, H.; Anderton, M.C.; Sim, E.; Dijkhuizen, L.; Davies, J.E.; Mohn, W.W.; Eltis, L.D. (2007). "A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages". Proc. Natl. Acad. Sci. USA. 104: 1947–1952. doi:10.1073/pnas.0605728104. PMID 17264217.
- ↑ Lack, N.; Lowe, E.D.; Liu, J.; Eltis, L.D.; Noble, M.E.; Sim, E.; Westwood, I.M. (2008). "Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64: 2–7. doi:10.1107/s1744309107065931. PMID 18097091.
- ↑ Lack, N.A.; Yam, K.C.; Lowe, E.D.; Horsman, G.P.; Owen, R.L.; Sim, E.; Eltis, L.D. (2010). "Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism". J. Biol. Chem. 285: 434–443. doi:10.1074/jbc.m109.058081. PMID 19875455.
External links
- 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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