3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase
| 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.60 | ||||||||
| CAS number | 9030-79-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase (EC 4.2.1.60, D-3-hydroxydecanoyl-[acyl-carrier protein] dehydratase, 3-hydroxydecanoyl-acyl carrier protein dehydrase, 3-hydroxydecanoyl-acyl carrier protein dehydratase, beta-hydroxydecanoyl thioester dehydrase, beta-hydroxydecanoate dehydrase, beta-hydroxydecanoyl thiol ester dehydrase, FabA, beta-hydroxyacyl-acyl carrier protein dehydratase, HDDase, beta-hydroxyacyl-ACP dehydrase, (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] hydro-lyase) is an enzyme with systematic name (3R)-3-hydroxydecanoyl-(acyl-carrier protein) hydro-lyase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- (1) a (3R)-3-hydroxydecanoyl-[acyl-carrier protein] a trans-dec-2-enoyl-[acyl-carrier protein] + H2O
- (2) a (3R)-3-hydroxydecanoyl-[acyl-carrier protein] a cis-dec-3-enoyl-[acyl-carrier protein] + H2O
This enzyme is specific for C10 chain length.
References
- ↑ Kass, L.R.; Brock, D.J.H.; Bloch, K. (1967). "β-Hydroxydecanoyl thioester dehydrase. I. Purification and properties". J. Biol. Chem. 242 (19): 4418–4431. PMID 4863739.
- ↑ Brock, D.J.H.; Kass, L.R.; Bloch, K. (1967). "β-Hydroxydecanoyl thioester dehydrase. II. Mode of action". J. Biol. Chem. 242 (19): 4432–4440. PMID 4863740.
- ↑ Sharma, A.; Henderson, B.S.; Schwab, J.M.; Smith, J.L. (1990). "Crystallization and preliminary X-ray analysis of β-hydroxydecanoyl thiol ester dehydrase from Escherichia coli". J. Biol. Chem. 265 (9): 5110–5112. PMID 2180957.
- ↑ Magnuson, K.; Jackowski, S.; Rock, C.O.; Cronan, J.E. Jr. (1993). "Regulation of fatty acid biosynthesis in Escherichia coli". Microbiol. Rev. 57 (3): 522–542. PMID 8246839.
- ↑ Bloch, K. (1969). "Enzymatic synthesis of monounsaturated fatty acids". Acc. Chem. Res. 2: 193–202. doi:10.1021/ar50019a001.
- ↑ Wang, H.; Cronan, J.E. (2004). "Functional replacement of the FabA and FabB proteins of Escherichia coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF homologues". J. Biol. Chem. 279: 34489–34495. doi:10.1074/jbc.M403874200. PMID 15194690.
- ↑ Cronan, J.E. Jr.; Rock, C.O. (1996). "Biosynthesis of membrane lipids". In Neidhardt, F.C. Escherichia coli and Salmonella: Cellular and Molecular Biology. 1 (2nd ed.). Washington, DC: ASM Press. pp. 612–636.
External links
- 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase at the US National Library of Medicine Medical Subject Headings (MeSH)
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