23S rRNA pseudouridine746 synthase
| 23S rRNA pseudouridine746 synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.4.99.29 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
23S rRNA pseudouridine746 synthase (EC 5.4.99.29, RluA, 23S RNA PSI746 synthase, 23S rRNA pseudouridine synthase, pseudouridine synthase RluA) is an enzyme with systematic name 23S rRNA-uridine746 uracil mutase.[1][2][3] This enzyme catalyses the following chemical reaction
- 23S rRNA uridine746 23S rRNA pseudouridine746
RluA is the only protein responsible for the in vivo formation of 23S RNA pseudouridine746.
References
- ↑ Hoang, C.; Chen, J.; Vizthum, C.A.; Kandel, J.M.; Hamilton, C.S.; Mueller, E.G.; Ferre-D'Amare, A.R. (2006). "Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure". Mol. Cell. 24: 535–545. doi:10.1016/j.molcel.2006.09.017. PMID 17188032.
- ↑ Raychaudhuri, S.; Niu, L.; Conrad, J.; Lane, B.G.; Ofengand, J. (1999). "Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA". J. Biol. Chem. 274: 18880–18886. doi:10.1074/jbc.274.27.18880. PMID 10383384.
- ↑ Wrzesinski, J.; Nurse, K.; Bakin, A.; Lane, B.G.; Ofengand, J. (1995). "A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for Ψ746 in 23S RNA is also specific for Ψ32 in tRNAPhe". RNA. 1: 437–448. PMID 7493321.
External links
- 23S rRNA pseudouridine746 synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia - version of the 5/16/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.