2-oxoglutaramate amidase

2-oxoglutaramate amidase
Identifiers
EC number 3.5.1.111
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

2-oxoglutaramate amidase (EC 3.5.1.111, omega-amidase) is an enzyme with systematic name 5-amino-2,5-dioxopentanoate amidohydrolase.[1] This enzyme catalyses the following chemical reaction

2-oxoglutaramate + H2O 2-oxoglutarate + ammonia

The enzyme participates in the nicotine degradation pathway of several Gram-positive bacteria.

References

  1. Cobzaru, C.; Ganas, P.; Mihasan, M.; Schleberger, P.; Brandsch, R. (2011). "Homologous gene clusters of nicotine catabolism, including a new ω-amidase for α-ketoglutaramate, in species of three genera of Gram-positive bacteria". Res. Microbiol. 162: 285–291. doi:10.1016/j.resmic.2011.01.001. PMID 21288482.

External links

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