2-hydroxy-dATP diphosphatase
| 2-hydroxy-dATP diphosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.6.1.56 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
2-hydroxy-dATP diphosphatase (EC 3.6.1.56, NUDT1, MTH1, MTH2, oxidized purine nucleoside triphosphatase, (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase) is an enzyme with systematic name 2-hydroxy-dATP diphosphohydrolase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- 2-hydroxy-dATP + H2O 2-hydroxy-dAMP + diphosphate
The enzyme hydrolyses oxidizes purine nucleoside triphosphates.
References
- ↑ Sakumi, K.; Furuichi, M.; Tsuzuki, T.; Kakuma, T.; Kawabata, S.; Maki, H.; Sekiguchi, M. (1993). "Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis". J. Biol. Chem. 268 (31): 23524–23530. PMID 8226881.
- ↑ Kakuma, T.; Nishida, J.; Tsuzuki, T.; Sekiguchi, M. (1995). "Mouse MTH1 protein with 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution". J. Biol. Chem. 270 (43): 25942–25948. doi:10.1074/jbc.270.43.25942. PMID 7592783.
- ↑ Fujikawa, K.; Kamiya, H.; Yakushiji, H.; Fujii, Y.; Nakabeppu, Y.; Kasai, H. (1999). "The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein". J. Biol. Chem. 274 (26): 18201–18205. doi:10.1074/jbc.274.26.18201. PMID 10373420.
- ↑ Sakai, Y.; Furuichi, M.; Takahashi, M.; Mishima, M.; Iwai, S.; Shirakawa, M.; Nakabeppu, Y. (2002). "A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1". J. Biol. Chem. 277: 8579–8587. doi:10.1074/jbc.M110566200. PMID 11756418.
- ↑ Fujikawa, K.; Kamiya, H.; Yakushiji, H.; Nakabeppu, Y.; Kasai, H. (2001). "Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP". Nucleic Acids Res. 29: 449–454. doi:10.1093/nar/29.2.449. PMID 11139615.
External links
- 2-hydroxy-dATP diphosphatase at the US National Library of Medicine Medical Subject Headings (MeSH)
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