2',3'-cyclic-nucleotide 2'-phosphodiesterase
| 2',3'-cyclic-nucleotide 2'-phosphodiesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.4.16 | ||||||||
| CAS number | 9037-18-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, a 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16) is an enzyme that catalyzes the chemical reaction
- nucleoside 2',3'-cyclic phosphate + H2O nucleoside 3'-phosphate
Thus, the two substrates of this enzyme are nucleoside 2',3'-cyclic phosphate and H2O, whereas its product is nucleoside 3'-phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase. Other names in common use include ribonucleoside 2',3'-cyclic phosphate diesterase, 2',3 '-cyclic AMP phosphodiesterase, 2',3'-cyclic nucleotidase, cyclic 2',3'-nucleotide 2'-phosphodiesterase, cyclic 2',3'-nucleotide phosphodiesterase, 2',3'-cyclic nucleoside monophosphate phosphodiesterase, 2',3'-cyclic AMP 2'-phosphohydrolase, cyclic phosphodiesterase:3'-nucleotidase, 2',3'-cyclic nucleotide phosphohydrolase, 2':3'-cyclic phosphodiesterase, and 2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase. This enzyme participates in purine metabolism and pyrimidine metabolism.
References
- ANRAKU Y (1964). "A NEW CYCLIC PHOSPHODIESTERASE HAVING A 3'-NUCLEOTIDASE ACTIVITY FROM ESCHERICHIA COLI B. I. PURIFICATION AND SOME PROPERTIES OF THE ENZYME". J. Biol. Chem. 239: 3412–9. PMID 14245396.
- ANRAKU Y (1964). "A NEW CYCLIC PHOSPHODIESTERASE HAVING A 3'-NUCLEOTIDASE ACTIVITY FROM ESCHERICHIA COLI B. II. FURTHER STUDIES ON SUBSTRATE SPECIFICITY AND MODE OF ACTION OF THE ENZYME". J. Biol. Chem. 239: 3420–4. PMID 14245397.
- Center MS, Behal FJ (1968). "A cyclic phosphodiesterase with 3'-nucleotidase activity from Proteus mirabilis". J. Biol. Chem. 243 (1): 138–43. PMID 4295113.
- Olafson RW, Drummond GI, Lee JF (1969). "Studies on 2',3'-cyclic nucleotide-3'-phosphohydrolase from brain". Can. J. Biochem. 47 (10): 961–6. doi:10.1139/o69-151. PMID 4310670.
- Unemoto T, Hayashi M (1969). "Chloride ion as a modifier of 2',3'-cyclic phosphodiesterase purified from halophilic Vibrio alginolyticus". Biochim. Biophys. Acta. 171 (1): 89–102. doi:10.1016/0005-2744(69)90108-9. PMID 4303200.