(6-4)DNA photolyase

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(6-4)DNA photolyase (EC 4.1.99.13, DNA photolyase, H64PRH, NF-10, phr (6-4), PL-(6-4), OtCPF1, (6-4) PHR, At64PHR) is an enzyme with systematic name (6-4) photoproduct pyrimidine-lyase.^[1]^[2] This enzyme catalyses the following chemical reaction

(6-4) photoproduct (in DNA)

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2 pyrimidine residues (in DNA)

This enzyme is a flavoprotein.

References

↑ Hitomi, K.; DiTacchio, L.; Arvai, A.S.; Yamamoto, J.; Kim, S.T.; Todo, T.; Tainer, J.A.; Iwai, S.; Panda, S.; Getzoff, E.D. (2009). "Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes". Proc. Natl. Acad. Sci. USA. 106: 6962–6967. doi:10.1073/pnas.0809180106. PMID 19359474.
↑ Schleicher, E.; Hitomi, K.; Kay, C.W.; Getzoff, E.D.; Todo, T.; Weber, S. (2007). "Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase". J. Biol. Chem. 282: 4738–4747. doi:10.1074/jbc.m604734200. PMID 17164245.

External links

(6-4)DNA photolyase at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon-carbon lyases (EC 4.1)

4.1.1: Carboxy-lyases	Acetoacetate decarboxylase Adenosylmethionine decarboxylase Aromatic L-amino acid decarboxylase Glutamate decarboxylase Histidine decarboxylase Lysine decarboxylase Malonyl-CoA decarboxylase Ornithine decarboxylase Oxaloacetate decarboxylase Phosphoenolpyruvate carboxykinase Phosphoenolpyruvate carboxylase Phosphoribosylaminoimidazole carboxylase Pyrophosphomevalonate decarboxylase Pyruvate decarboxylase RuBisCO Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase Uroporphyrinogen III decarboxylase

4.1.2: Aldehyde-lyases	Fructose-bisphosphate aldolase Aldolase A Aldolase B Aldolase C 2-hydroxyphytanoyl-CoA lyase Threonine aldolase

4.1.3: Oxo-acid-lyases	Isocitrate lyase 3-hydroxy-3-methylglutaryl-CoA lyase

4.1.99: Other	Tryptophanase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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